Molecular and Genetic Medicine

Frequency of ABCG2 421C>A Genetic Variant and The Efficiency of Treatment with Rosuvastatin in Kazakh Male Patients

Abstract

Kozhakhmetov SS, Kushugulova AR, Kakimova AB, Saduakhassova SA, Urazova ?S, Khassenbekova ZHR, Kozhakhmetova SS, Beysembayeva SCH, Sibagatova AS, Tuleutayeva GK, Urazbayeva GS, Ongarbayeva AE, Yakovenko GI, Kissikova SL and Nurgozhin ?S

Rosuvastatin is one of the most effective lipid-lowering drugs. Nevertheless its activity varies in different populations. Important role in this belongs to ABCG2. The objective of this study was to determine the impact of ABCG2 genotype on therapeutic effect of rosuvastatin in Kazakh population. This study included 82 Kazakh patients with metabolic disorder undergoing 10 -20 mg/day of rosuvastatin therapy for 12 weeks. Our findings indicated that people with 421AA genotype had higher response to the drug. The frequency of minor alleles in the studied group was 29.5%.