Cardiovascular Disease (CVD) is the leading cause of death in women worldwide. The burden of CVD is rising among Arab Middle Eastern (ME) women. Information regarding the prevalence and incidence of CVD and its risk factors in women in Arab ME is scares and may be lacking in some countries. One of the reasons is low participation of Arab women in cardiovascular trials and research. The underlying reasons for the under-representation of women in clinical trials are complex and exploration of additional causes, such as socioeconomic and psychological factors is crucial to help us to address the gap in scientific evidence on women with cardiovascular disease in the Arab region.