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Innovations In Drug Discovery | Open Access Journals
Clinical Infectious Diseases: Open Access

Clinical Infectious Diseases: Open Access

ISSN: 2684-4559

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Innovations In Drug Discovery

Treating triple negative breast cancer (TNBC) is a challenge for oncologists. Currently, the lack of effective therapy has favored a major effort to discover new targets and therapies to combat this disease. The Nantes-based receptor (RON) receptor has been implicated in the pathogenesis of TNBC. Clinical studies have shown that the aberrant expression of RON is crucial in the regulation of TNBC malignant phenotypes. Increased expression of RON also has prognostic value for the progression of breast cancer. These characteristics provide the rationale for targeting the RON for TNBC treatment. In this review, we discuss the importance of RON in TNBC tumorigenesis and the development of anti-RON antibody-drug (ADC) conjugates for clinical application. The results of preclinical studies lay the foundation for clinical trials of this new biotherapeutic for TNBC therapy.

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Clinical Infectious Diseases: Open Access received 1149 citations as per Google Scholar report

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