Molecular Biology: Open Access

ISSN: 2168-9547

Open Access

Xing Liang

The State Key Laboratory of Oral Diseases,
West ChinaHospital of Stomatology, Chengdu, Sichuan

  • Research Article
    Role of Cx43-Based Gap Junction in Murine Osteoblast-Like Mc3t3-E1Cells Exposed to 17-├?┼Ż├?Ô??estradiol
    Author(s): Zhenzhen Shang, Ting Wei and Xing LiangZhenzhen Shang, Ting Wei and Xing Liang

    Estrogen has garnered considerable attention because of its importance in bone mass maintenance and the efficacy of hormone therapy in combating postmenopausal osteoporosis. Gap junctions are membrane spanning protein channels present on the surfaces of adjacent cells. They enable neighboring cells to physically link, which facilitate intercellular communication by allowing passage of small molecules from cell to cell in a process known as Gap Junctional Intercellular Communication (GJIC), can make the relevant cells function as a whole. An in vitro experiment combined with microarray analyses has identified novel genes in the response of MC3T3-E1 cells to an appropriate concentration of 17-β estradiol and the results of microarray showed that gap junction alpha-1 (Gja1) in the gap junction pathway was significantly elevated. We studied the effect of 17-β estradiol on the pr.. Read More»
    DOI: 10.4172/2168-9547.1000197

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