Molecular Biology: Open Access

Adugnaw Admas

Publications

• Research Article
  The Frequency and Effects of CCR5 Delta 32 Allele in Gondar Population
  Author(s): Adugnaw AdmasAdugnaw Admas
  
  HIV is the virus that causes AIDS. Its infection occurs by binding to CD4+ receptor and chemokine receptor 5 (CCR5). Recent studies have shown that reasons for progression and non-progression are multi factorial and may involve genetic, virological and immunological factors that influence HIV disease progression in various ways. Chemokine receptors act as important co receptors mediating the entry of the human immunodeficiency virus type 1 (HIV-1) into susceptible cells. The Δ32 mutation at the CCR5 locus is a well-studied example of natural selection acting in humans. Homozygous carriers of the Δ32 mutation are resistant to HIV-1. The aim of the present study was to assess the frequency of CCR5-Δ32 (Chemokine receptor delta 32 allele) in HIV-1 untreated individuals who visited Gondar university teaching hospital. 3 ml blood samples of fifty HIV-.. Read More»
  DOI: 10.4172/2168-9547.1000168

  Abstract PDF