Journal of Clinical Case Reports

Quetiapine-Induced Atypical Neuroleptic Malignant Syndrome (NMS): A Case Report

Abstract

Charanya T, Aneelraj D, Sivaprakash B and Eswaran S

NMS is an iatrogenically caused medical emergency, by D2 receptor blocking drugs. Atypical NMS is a presentation of three of the four signs-hyperthermia, rigidity or other extrapyramidal syndromes, autonomic disturbances and mental status changes. We report a case of a 41-year-old male with multiple drug abuse, dysthymia with moderate depressive episode and hypertension who developed Atypical NMS when on treatment with quetiapine. Atypical NMS resolved within a week of discontinuation of quetiapine and with supportive care. Atypical NMS is an impending state of NMS, which needs to be identified at the earliest to avert further complications.