Journal of Clinical Case Reports

Granular Cell Tumor of Vulva: Differentiation from Malign Lesions

Abstract

Gokcen Coban*, Nefise Cagla Tarhan, Ozlem Ozen and Ali Ayhan

Granular Cell Tumors (GCT) is very uncommon tumors and was first described by Abrikossoff in 1926. They are small, painless, slow-growing subcutaneous nodules most commonly seen in the tongue and oral mucosa. 5-16% of the granular cell tumors have been reported in the vulva. To our knowledge, the imaging findings of GCT of the vulva were not described in the literature before. In this case, we present the imaging findings of a 63-years-old female who had GCT of the vulva. On ultrasonography there was ill-defined, lobulated heterogeneous solid mass with central hypoechoic and peripheral slightly hyperechoic areas in vulvar subcutaneous fat. On MRI, the tumor was hypointense on T1 and T2-weighted images compared to fat tissue, isointense with muscles on T1-weighted images and on T2-weighted images slightly iso-hyperintense with muscles. Dynamic examination showed early diffuse enhancement more peripherally, which were also continuing on late phase images. On CT, the tumor was isodense to adjacent muscles and showed minimal enhancement. There were no regional or distant metastasis and no lymphadenopathy. The tumor was treated by wide surgical excision and pathology was consistent with granular cell tumor.