Journal of Clinical Case Reports

Antibiotic Susceptibility Pattern of Gram-Negative Bacteria Isolated from Infected Wound of Patients in Two Health-Care Centers in Gboko Town

Abstract

 Terwase Jerry1, Agah Torkwase Queen2, Ichor Tersagh1* and Ebah Esther1

The rising cases of multi-drug resistant bacteria have received considerable attention from patients and clinicians as a result of difficulties encountered during treatment. This has posed great challenges to pharmaceutical practitioners for continued search for effective antibiotics. The present study aimed at investigating antibiotic susceptibility profile of Gram-negative bacteria isolated from infected wound in two selected privately owned healthcare centers in Gboko town. A total of thirty (30) wound samples, fifteen (15) from each of the hospital were collected using swab sticks and analyzed and the isolates tested for MDR using disc diffusion method. The result showed that the wounds were infected with Escherichia coli (46.7%), Salmonella spp (40%) and Pseudomonas spp (13.3%). The three isolates displayed varying degrees of resistance to antibiotics. Escherichia coli showed the highest resistance to streptomycin (92.8%), Augmentin (92.8%), Septrin (78%), Gentamycin (78.5%), Amoxacillin (71.4%) and Chloramphenicol (71.4%) and least resistance was observed with Pefloxacin (50%), Tarivid (50%), Sparfloxacin (57%), Ciprofloxacin (50%) antibiotics. Salmonella spp showed the highest resistance to Septrin (100%), Augmentin (91%), Streptomycin (91%), Amoxacillin (83.3%), Chloramphenicol (83.3%), Tarivid (83.3%) and least resistance to Sparfloxacin (33.3%), Ciprofloxacin (41.6%) and Pefloxacin (41.6%) antibiotics. Pseudomonas spp showed (100%) resistance to Gentamycin, Augmentin, Amoxacillin, Ciprofloxacin, Sparfloxacin, Septrin and Streptomycin, though the resistance was observed to be slightly minimal to Pefloxacin (75%), as well as Tarivid and Chloramphenicol. Antibiotic susceptibility test is recommended prior to administration of antibiotics for effective treatment and periodic monitoring is also advocated to check emerging MDR trends as a guide to health authorities.