Molecular Biomarkers & Diagnosis

Yongwoo Hwang

Publications

• Research Article
  A Metabonomic Study on Samples of Cutaneous Leishmaniasis and its Correlation with the Selenium Level in the Blood Serum
  Author(s): Tafazzoli Mohsen, Fathi Fariba, Darvizeh Fatemeh, Zahra Zamani and Pourfallah FatemehTafazzoli Mohsen, Fathi Fariba, Darvizeh Fatemeh, Zahra Zamani and Pourfallah Fatemeh
  
  This paper presents the result of extensive experiments on the blood serum samples of 20 leishmaniasis patients and 44 healthy individuals using nuclear magnetic resonance (NMR) spectroscopy and the Chenomx software. The concentrations of selenium in all 64 serum samples were also measured using an atomic absorption device. The healthy and patient groups were completely differentiated using the partial least square method (PLS). In addition, important variables that could highly infl uence the group of patients were detected by the PLS loading plot. This paper also presents the results corresponding to linear and non-linear modeling of selenium concentration in serum. Stepwise multiple linear regression (MLR) was used to select the fi ve most important descriptors. In the multiple linear regression modeling approach the results obtained for R2 training, test and validation sets were 0.. Read More»
  DOI: 10.4172/2155-9929.1000101

  Abstract PDF