Journal of Hypertension: Open Access

Vladimir Micovic

Publications

• Research Article
  Impacts of Exogenously Derived Nitrogen Oxide and Sulfur Compounds on the Structure and Function of the Vascular Endothelium Link Pregnancy Hypertension with Later Life Hypertension
  Author(s): Lucijan Mohorovic, Eris Materljan, Vladimir Micovic, Dulija Malatestinic, Sanja Stifter and Anna M. LavezziLucijan Mohorovic, Eris Materljan, Vladimir Micovic, Dulija Malatestinic, Sanja Stifter and Anna M. Lavezzi
  
  The relationship between pregnancy hypertension and later life hypertension is explained by long-term impacts of environmental oxidants on the vascular endothelium. These impacts may precede the onset of the disease as a primary defect and may participate in the pathogenesis of hypertension itself. Continuous exposure to strong exogenous oxidants such as NOx (NO and NO 2 ) reversibly oxidizes oxyhemoglobin (Fe 2+ ) to methemoglobin (Fe 3+ ), and irreversible methemoglobinemia can arise because of disruption of the oxidant/antioxidant balance supported by SO 2 metabolites, as inhibitors of antioxidants, and by synergistic degradation of antioxidant thiols . Methemoglobin by itself and from heme, redox-active ferric iron as product of methemoglobin catabolism, have prooxidant properties and cause important structural and functional changes in the vascular endothelium such as growth arre.. Read More»
  DOI: 10.4172/2167-1095.1000103

  Abstract PDF