Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Shui Qing Ye

Children’s Mercy Hospitals and Clinics,
2401 Gillham Road, PRC/4th FL, Kansas City, MO 64108

  • Research Article
    Nicotinamide Phosphoribosyltransferase in Human Diseases
    Author(s): Li Qin Zhang, Daniel P. Heruth and Shui Qing YeLi Qin Zhang, Daniel P. Heruth and Shui Qing Ye

    Nicotinamide phosphoribosyltransferase (NAMPT) was first reported as a pre-B-cell colony enhancing factor in 1994 with little notice, but it has received increasing attention in recent years due to accumulating evidence indicating that NAMPT is a pleiotropic protein such as a growth factor, a cytokine, an enzyme and a visfatin. Now, NAMPT has been accepted as an official name of this protein. Because of NAMPT’s multiple functions in a variety of physiological processes, their dysregulations have been implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis. This review will cover the current understanding of NAMPT’s structure and functions with an emphasis on recent progress of nicotinamide phosphoribosyltransferase’s pathological roles in var.. Read More»
    DOI: 10.4172/1948-593X.1000038

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