Journal of Nephrology & Therapeutics

Nasser W

Publications

• Case Series
  Transient Pseudohypoaldosteronism in Childrens Secondary to Urinary Tract Infection: Literature Review and Report of 2 Cases
  Author(s): Nasser S, Nasser H, Michael J, Soboh S, Ehsan N, Shhadi S, Boshra N and Nasser WNasser S, Nasser H, Michael J, Soboh S, Ehsan N, Shhadi S, Boshra N and Nasser W
  
  Pseudohypoaldosteronism (PHA) types I and II share hyperkalemia as a predominant finding. PHA is a heterogeneous syndrome characterized by a lack of response of the organs to the mineralocorticoid, and therefore there is loss of salts. Heredity can be autosomal dominant or recessive. It is very rare for other mutations to occur. Autosomal dominant PHA-I is characterized by mutations in the mineralocorticoid receptor, while Autosomal recessive PHA-I results from mutations in the epithelial sodium channel (ENaC). Clinical expression of renal PHA-I is variable: patients present with salt loss in the neonatal period, failure to thrive, vomiting, and dehydration. Symptoms of renal PHA-I often improve in early childhood and older children. PHA-II is the result of mutations in a family of serine-threonine kinases called with- no-lysine kinases (WNK) 1 and WNK4. The predom.. Read More»
  DOI: 10.37421/jnt.2019.9.340

  Abstract PDF