Journal of Bioanalysis & Biomedicine

Marcellino Monda

Publications

• Research Article
  Effects of Orexin A on Thermal Behaviour: Substantial Evidences for Thermoregulatory Role of Orexin A
  Author(s): Emanuela Viggiano, Giovanni Messina, Andrea Viggiano, Alessandro Viggiano, Vincenzo De Luca, Antonietta Messina and Marcellino MondaEmanuela Viggiano, Giovanni Messina, Andrea Viggiano, Alessandro Viggiano, Vincenzo De Luca, Antonietta Messina and Marcellino Monda
  
  Orexin A is a hypothalamic neuropeptide produced in the dorsal and lateral hypothalamus, and orexin-producing cell have widespread anatomical projections within the central nervous system. Orexin A is involved in multiple physiological functions, including eating behavior, thermoregulation, and sleep-regulation. The aim of this work was to study the thermal preference induced by orexin A. A thermal preference task with floor thermal gradient from 16°C to 25°C, divided into 10 equal segments, was designed to evaluate the thermal preferences in rats. Male rats (n=10, divided into two groups of five animals) received an intracerebroventricular injection of 1.5 nmol of orexin A or vehicle and were subsequently tested for thermal preference for 4 h. The results showed that the rats injected with orexin A had increased motor activity compared to the control group, particularly after.. Read More»
  DOI: 10.4172/1948-593X.1000108

  Abstract PDF