Journal of Hypertension: Open Access

Li-Na Zhang

Publications

• Research Article
  Association between ADD1 Gly460Trp Polymorphism and Essential Hypertension in Han Chinese
  Author(s): Pan-Pan Liu, Qi-Long Zhong, Fang Yuan, Fa-De Zhong, Rui Fan, Li-Juan Fei, Ling-Mei Hao, Xu-Jun Qiu, Shiwei Duan and Li-Na ZhangPan-Pan Liu, Qi-Long Zhong, Fang Yuan, Fa-De Zhong, Rui Fan, Li-Juan Fei, Ling-Mei Hao, Xu-Jun Qiu, Shiwei Duan and Li-Na Zhang
  
  Background: The ADD1 Gly460Trp polymorphism has been linked to essential hypertension (EH) in multiple populations, but the results were inconsistent. The goal of our study is to investigate the contribution of ADD1 Gly460Trp polymorphism and environmental factors to the risk of EH. Methods: We conducted a case-control study including 1020 hypertensive cases and 1020 controls, and the gender and age were well matched between hypertensive and control groups. Blood samples and participants information were also collected. Using the melting temperature shift technology, the ADD1 Gly460Trp polymorphism was genotyped among all subjects. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the ADD1 Gly460Trp polymorphism and the nongenetic factors. Results: Our results showed that body m.. Read More»
  DOI: 10.4172/2167-1095.1000145

  Abstract PDF