Journal of Inflammatory Bowel Diseases & Disorders

ISSN: 2476-1958

Open Access

Jay Pravda

Gastro One, 8000 Wolf River Blvd.,
Germantown, Tennessee 38138

  • Research Article
    Novel Combination Therapy Induced Histological Remission in Patients with Refractory Ulcerative Colitis
    Author(s): Jay Pravda, Michael J Weickert and Lawrence D WrubleJay Pravda, Michael J Weickert and Lawrence D Wruble

    Objectives: In many patients, Ulcerative Colitis (UC) is poorly controlled; patients frequently fail to achieve remission or relapse on current therapies. Multiple disease mechanisms have been postulated but resulting therapies fail to deliver complete histological and clinical remission in a majority of patients. This case series reports clinical experience treating patients with active UC, not responding to conventional therapies, with a combination enema and oral therapy, to test whether it could induce remission in refractory, moderate to severe disease. Methods: A four-component enema consisting of approved medications and generally regarded as safe ingredients, and oral dihydrolipoic acid, was administered daily for up to eight weeks. Thirty-six patients with UC experiencing a current flare not responding to other UC medications were tre.. Read More»

    Abstract PDF

Relevant Topics

arrow_upward arrow_upward