Nuclear Medicine & Radiation Therapy

ISSN: 2155-9619

Open Access

David Murray

Division of Experimental Oncology,
Edmonton, Alberta

  • Research Article
    Role of Therapy-Induced Cellular Senescence in Tumor Cells and its Modification in Radiotherapy: The Good, The Bad and The Ugly
    Author(s): David Murray and Razmik MirzayansDavid Murray and Razmik Mirzayans

    The last decade has seen major advances in the clinical practice of radiotherapy (RT). Our understanding of the biological effects occurring after exposure of cells and tissues to ionizing radiation has also increased enormously in this period. In this article we will summarize our current knowledge and key knowledge gaps in an area that is emerging as a potentially important factor in tumor responses to RT, namely the activation of the therapy-induced cellular senescence (TCS) pathway and its associated secretory response, the so-called senescence-associated secretory phenotype or “SASP”. Although the existing literature on these responses is substantial in the chemotherapy domain, the information specific to RT has unfortunately lagged behind. This includes knowledge relating to the factors that govern the ability of tumor cells to switch from TCS to another terminal/irr.. Read More»
    DOI: 10.4172/2155-9619.S6-018

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