Journal of Tissue Science and Engineering

Yong-Jang Chen

Publications

• Research Article
  The Potential Therapeutic Cells in Vascular Dementia: IL-1beta Enhanced Endothelial Progenitor-like Cells
  Author(s): Yi-Chien Lin, Pei-Yi Tsai, Chun-Ming Cheng, Yong-Jang Chen and Jia-Ming ChangYi-Chien Lin, Pei-Yi Tsai, Chun-Ming Cheng, Yong-Jang Chen and Jia-Ming Chang
  
  Vascular Dementia (VaD) is a neurodegenerative disease caused by vascular lesions that leads to reduced Cerebral Blood Flow (CBF). We investigated the potential of Endothelial Progenitor-like Cells (EPC-like cells) in mitigating dementia symptoms by improving the endothelial remodelling in the ischemic VaD mice. EPC-like cells could be differentiated from CD117 positive bone marrow cells with cytokines, e.g. VEGF, b-FGF, EGF, IL-1β and IGF-1, and then characterized by surface markers (CD117+, CD31+, Tie2+ and VE-Cadherin+) and biological function of tube formation and LDL uptake. The feasibility in treating VaD was assessed by using the carotid artery ligation VaD mouse model. Among EPC-like cells, about 93% of cell population expressed CD117 molecules and 27% of cell population expressed CD31 molecules, which demonstrated the ability for the tube formation and phagocytosis. Half.. Read More»
  

  Abstract PDF