Journal of Clinical & Medical Genomics

Oleksandr H Minchenko

Publications

• Research Article
  IRE-1 Dependent Expression of Phosphoribosyl Pyrophosphate Synthetase Genes in U87 Glioma Cells: Effect of Glucose or Glutamine Deprivation
  Author(s): Dmytro O Minchenko, Iana A Garmash, Yulia M Bashta, Ganna S Kustkova, Yulianna D Zalesna, Andreas Bikfalvi and Oleksandr H MinchenkoDmytro O Minchenko, Iana A Garmash, Yulia M Bashta, Ganna S Kustkova, Yulianna D Zalesna, Andreas Bikfalvi and Oleksandr H Minchenko
  
  Nutrient deprivation conditions are capable to induce the endoplasmic reticulum stress and are responsible for regulation of the expression of numerous growth factors which control the cell proliferation and angiogenesis in malignant tumors, including glioma. The ERN1 mediated endoplasmic reticulum stress response-signalling pathway is tightly linked to the proliferation because the blockade of ERN1 function suppresses the tumor growth via specific changes in the cell transcriptome. Activation of the pentose phosphate pathway is an important factor of enhanced cell proliferation and tumor growthbecause it controls the synthesis of nucleotides and respectively nucleic acids. We studied the effect of blockade the ERN1 signaling enzyme function in glioma cells on the expression of phosphoribosyl pyrophosphate synthetase (PRPS), an important enzyme of pentose phosphate pathway, as well as.. Read More»
  DOI: 10.4172/2332-0672.1000104

  Abstract PDF