Journal of Clinical & Medical Genomics

Muhammad Nauman Sharif

Publications

• Research Article
  Association between Vitamin D Receptor (VDR) Gene Polymorphisms and Type-2 Diabetes Mellitus in Population of Pakistan
  Author(s): Zia Ashraf, Mehwish Ameen, Shahbaz Ahmad, Hamid Manzoor, Muhammad Gulshair and Muhammad Nauman SharifZia Ashraf, Mehwish Ameen, Shahbaz Ahmad, Hamid Manzoor, Muhammad Gulshair and Muhammad Nauman Sharif
  
  Vitamin D is known to have antiproliferative, antioxidant and immunosuppressive effect and has known association with diabetes risk. Vitamin D acts through its receptor, the Vitamin D Receptor (VDR). VDR has many Single Nucleotide Polymorphisms (SNPs) of which Apa I and Taq I have been widely studied. The present study is based on correlation of VDR gene polymorphisms with diabetes patients from Southern Punjab, Pakistan. A sumof 250 samples comprising normal controls (100) and diabetes patients (150) was collected from different areas of South Punjab, Pakistan. All of the samples were genotyped for VDR genotypes at allelic positions of rs7975232 (Apa I) and rs731236 (Taq I). Allelic frequencies were not different between controls and patients. Statistical correlation was insignificant between control and diabetics. Enrolled subjects were assayed for.. Read More»
  DOI: 10.4172/2472-128X.1000153

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