Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Kang Yang

IR Iran

  • Research Article
    NMDA Receptors and Epileptogenesis in Human Cortical Dysplasia: A Metaanalysis
    Author(s): Kang Yang, Ce Zhang, Jing Su, Yue Lang and Jian YinKang Yang, Ce Zhang, Jing Su, Yue Lang and Jian Yin

    Cortical dysplasia (CD) is a cerebral disorder caused by disruption of neuronal migration and disorganization of cortex development. The mechanisms of epileptogenicity in CD have been investigated yet still remain unknown. One of the possible reasons is the changes of expression of Nmethyl-D-aspartate (NMDA) receptors. Emerging evidences have shown that NR2A/B in the region of focal cortical dysplasia (FCD) cortex may play an important role in the risk of epilepsy and NR1 remains unchanged during epilepsy pathogenesis but recent published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the associations between NMDA receptors and CD related epilepsy risk. A literature search of PubMed, Embase, Web of Science and China BioMedicine (CBM) databases was conducted on articles published before July 1st, 2013. Crude odds ratio (OR) with 95%.. Read More»
    DOI: 10.4172/2157-7099.1000208

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