Reference interval for serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) biomarker for diagnosing acute kidney injury

12^th Global Nephrologists Annual Meeting

June 26-28, 2017 London, UK

Chidum Ezenwaka, Saleh Idris and Gershwin Davis

The University of the West Indies, St. Augustine Campus, Trinidad and Tobago

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is emerging as a promising biomarker for diagnosing acute kidney injury, yet its reference interval is not established in many populations. This report documents serum NGAL reference intervals in apparently healthy population in the Caribbean. The blood pressure (BP), height and weight of 90 (37 males, 53 females) apparently healthy subjects aged between 17 and 83 years were measured. Fasting blood samples were collected and serum NGAL levels were measured with manual Enzyme Linked Immunosorbant Assay (ELISA) method. The Statistical Package for the Social Sciences (SPSS) was used for statistical analysis. The results showed that the age, BP and Body Mass Index (BMI) were similar in male and female subjects studied (p>0.05). NGAL levels showed a normal Gaussian frequency distribution and were similar in male and female subjects, and did not also differ between two age categories (<60 yr. and >60 yr; p>0.05). We report that the overall unisex reference interval for the population is 47-55 ng/ml while the gender- and age-specific reference intervals for serum NGAL are (male: 98.9-115 ng/ml, female: 108.4-121.9 ng/ml) and <60 yr (47-54 ng/ml) and >60 yr (35.7-71.6 ng/ml) respectively. The present study reports reference intervals specific for two age categories and gender in a Caribbean population and recommends further investigations on serum NGAL reference intervals in different populations.

Biography :

Email: ezenwaka@yahoo.com