Influence of bushenhuoxue on podocytes of focal segmental glomerulosclerosis mice

8^th World Nephrology Conference

August 15-16, 2016 Sao Paulo, Brazil

Mianzhi Zhang

Tianjin GongAn Hospital, China

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Focal segmental glomerulous sclerosis (FSGS) is a common, difficult to treat glomerular disease that can eventually lead to endstage renal disease (ESRD). Its pathogenesis is not entirely clear, and treatment methods remain controversial. Many studies have shown that podocyte injury at different stages is a key event of FSGS pathology. Consequently, protecting injured podocytes has become a key aspect of current FSGS treatments. The podocyte is an intrinsic, highly specialized kidney cell with limited regenerative ability. It is difficult for the podocyte to repair itself and proliferate when it is damaged or reduced. Podocyte mutations and changes in their numbers and distribution can cause structural changes and induce albuminuria and glomerular sclerosis. Treatment of FSGS using western medicine showed no cure, expensive, and there are serious side effects. Traditional Chinese medicine could offer an effective way to treat FSGS. Bushenhuoxue was used to treat and cure renal diseases; Bushenhuoxue comprises greater than ten kinds of Chinese herbal medicines that promote blood circulation and Qi, remove blood stasis, and tonify the kidney. We focused on desmin, nephrin and wt1 expression in podocytes of FSGS mice, and their regulation by Bushenhuoxue. We also sought to elucidate the protective mechanisms of Bushenhuoxue on injured podocytes.

Biography :

Email: zhangmianzhi@vip.sina.com