DOI: 10.37421/2168-9547.2023.12.396
Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. The disease is characterized by the accumulation of amyloid-beta plaques and neurofibrillary tangles in the brain, which lead to the loss of neurons and cognitive decline. While the exact causes of Alzheimer's disease are not fully understood, recent research has shed light on the molecular biology and genetics underlying the disease. One of the key molecular features of Alzheimer's disease is the accumulation of plaques in the brain. Peptide that is produced through the cleavage of the Amyloid Precursor Protein (APP) by the enzymes. In healthy individuals, brain through a variety of mechanisms, including enzymatic degradation and clearance by immune cells. However, in Alzheimer's disease, accumulates in the brain, forming plaques that are toxic to neurons.
Divyalakshmi Saini and Vinay Jain
Telomeres have always been an enigmatic structure since their discovery. The unravelling of new findings and changing concept of central dogma
at telomeres have intrigued the telomere biologists further. Telomeres have been considered antennas for various environmental stress and
detectors of cellular DNA damage. The translation of mammalian telomeres has further raised many questions about its involvement in maintaining
the genomic integrity and have opened doors for new era of research in telomere biology and telomere-related diseases. Unravelling the mysteries
of telomeric organization and its regulation will have widespread impact in various fields including cancer treatment, space exploration and aging
disorders.
The Endoplasmic Reticulum (ER) is a vital organelle responsible for protein folding, lipid synthesis, and calcium homeostasis within the cell. Under conditions of cellular stress, such as nutrient overload or disturbances in calcium levels, the ER can become dysregulated, leading to a state known as endoplasmic reticulum stress. ER stress has been implicated in various metabolic disorders, including obesity and type 2 diabetes. One key aspect of metabolic regulation affected by ER stress is adipogenesis, the process by which precursor cells differentiate into adipocytes. This article explores the mechanisms underlying ER stress, its role in adipogenesis, and its implications for metabolic health.
Bacterial Extracellular Vesicles (EVs) have emerged as key mediators in intercellular communication and host-microbe interactions. In this article, we delve into the biogenesis and functions of bacterial EVs, with a focus on their implications in plant-microbe interactions. Understanding the roles of EVs in microbial communication and their influence on plant health holds significant potential for agricultural and environmental applications.
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, pose significant challenges to global healthcare systems due to their debilitating nature and lack of effective treatments. Recent research has shed light on the intricate interplay between oxidative stress and inflammatory responses in the pathogenesis of these disorders. This article explores emerging insights into the roles of oxidative stress and inflammation in neurodegeneration, highlighting potential therapeutic targets and strategies for mitigating disease progression.
Maxence Dubreucq
Abdus Xiong
Molecular Biology: Open Access received 607 citations as per Google Scholar report